Scientists Discover New Cause for Chronic Constipation

Scientists from Nagoya University have identified two gut bacteria, Akkermansia muciniphila and Bacteroides thetaiotaomicron, responsible for chronic constipation by degrading the colon's protective mucus layer. This mucus is vital for lubricating the colon and keeping stool moist. The breakdown leads to hard, dry stool, rendering traditional laxatives ineffective. Moreover, higher levels of these bacteria have been found in Parkinson's patients, linking gut bacteria to early symptoms. Blocking the mucus-degrading enzyme in mice showed promising results in preventing constipation. This research suggests targeting bacterial activity could be a new treatment approach.