Scientists Identify Natural Inflammation 'Off Switch'

Researchers at University College London have discovered a natural mechanism in the body using molecules called epoxy-oxylipins to shut down inflammation once it's no longer needed. These molecules prevent harmful immune cell buildup linked to chronic conditions such as arthritis and heart disease. In a study published in Nature Communications, participants treated with a drug enhancing these molecules experienced reduced pain and lower inflammatory cell levels. The research opens avenues for safer treatments targeting chronic inflammation, with potential trials on sEH inhibitors that may benefit rheumatoid arthritis and cardiovascular diseases.